Palmitoylethanolamide (PEA) 400mg 50 Capsules


PEA plays a role in a wide variety of biological functions related to pain and possesses anti-inflammatory, anti-nociceptive and neuroprotective properties.

PEA is a fatty acid molecule naturally found in the body and is obtained from protein rich foods such as egg yolk, soybean and meat. It acts as an anti-inflammatory and analgesic by targeting nervous system cells that increase pain and turning them off when they are not needed anymore.


The main target of PEA is thought to be the peroxisome proliferator-activated receptor alpha (PPAR). This receptor is a regulator of gene networks which control pain and inflammation. PEA also has affinity to cannabinoid-like G protein-coupled receptors GPR55 and GPR119. PEA can influence ion channels (e.g., potassium channels) that play a role in pain. Furthermore, PEA may desensitise transient receptor potential action channel subfamily V member channels on sensory neurons.

Many chronic pain sufferers exhibit low levels of PEA and supplementation is thought to restore the body’s P.E.A. levels and help combat the pain response.

Additional information

Weight 0.06 kg
Dimensions 5.5 × 5.5 × 7 cm