Low Dose Naltrexone (LDN)

Low dose Naltrexone (LDN)

Low dose Naltrexone (LDN) refers to Naltrexone at doses below 10mg per day. At these doses, Naltrexone exhibits novel and paradoxical effects.

Successful treatment of chronic pain has been found with naltrexone at low dosages. Theoretically, a complete blockade of endogenous opioid systems would not be a desirable outcome with a chronic pain patient.  Although it is unusual for a drug to have an opposite effect when given at a low dosages, this has been proven in several cases for opioid-related drugs in particular. Findings show that doses to cause paradoxical hyperalgesia are approximately 1/10th of the dosage typically used to produce analgesia.

Studies have shown it can take 8-10 weeks to determine if you will respond to the drug. It is not recommended to stop taking it before this period of time.

Mechanism of Action

Naltrexone when used in a lower dose has Immunomodulatory, opiate blocking and anti-tumour effects for 4-6 hours

The Levo Naltrexone molecule binds to opiate receptors decreasing the release of glutamate neurotransmitters. This inhibits microglial activation and suppresses the activation of NMDA receptors causing:

  • A rebound effect that increases endorphin release
  • Increases sensitivity of existing opiate/endorphin receptors
  • More Opiate receptors are formed to capture endorphins

Dose Forms

  • Liquid
  • Capsules
  • Cream


An order can be placed by providing us with the script. This can initially be through email, fax or online.

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