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Magnesium For Pain Relief

The beneficial effects have been observed in a variety of patients with neuropathic pain such as

  • Malignancy-related neurologic symptoms
  • Post herpetic neuralgia
  • Diabetic neuropathy
  • Chemotherapy-induced peripheral neuropathy


Furthermore, magnesium therapy has been recognised as effective in alleviating dysmenorrhoea, headaches, and acute migraine attacks.


Magnesium balances out calcium which in turn relaxes nerve cells and to stops them from firing off pain signals.


Magnesium has a significant role in preventing central sensitization as well as reducing established pain hypersensitivity. It is apparent that Magnesium's primary mode of action involves its voltage-gated antagonist action at N-methyl-D-aspartate (NMDA) receptors.


NMDA receptors facilitate neuronal influx of calcium, resulting in a state of hyper excitation, which results in increased response to following stimuli; a phenomenon known as ‘NMDA wind-up’. Pain signalling can be prevented by blocking the neural influx of calcium. This is archived by occupying the magnesium binding site on the NMDA receptors.


Slight deficiencies of magnesium can result in muscles beginning to spasm, and the pain is amplified by sensitive nerves. Self-care with magnesium prompts a positive feedback loop that allows your body to recuperate.

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